Stockholders who wish to communicate directly with our Board of Directors, or any individual director, should direct questions in writing to the address provided below. Communications addressed in this manner will be forwarded directly to the Board of Directors or named individual director.

Sage Therapeutics, Inc.
Attn: Corporate Secretary
215 First St.
Cambridge, Massachusetts 02142

Other Communications
Anyone who wishes to report complaints regarding the Company's accounting, internal accounting controls, auditing matters or other compliance concerns may do so in writing at the address provided or confidentially and anonymously, where permitted by local law, by using the Compliance Helpline. Complaints submitted in this manner will be forwarded directly to the Chair of the Audit Committee.

Compliance Helpline:
To submit a report online go to: http://www.openboard.info/SAGE/
To submit a report over the phone dial: 877-215-0214